Insulin resistance and altered glucose transporter 4 expression in experimental uremia
نویسندگان
چکیده
منابع مشابه
Impaired regulation of glucose transporter 4 gene expression in insulin resistance associated with in utero undernutrition.
The aim of this study was to investigate whether insulin resistance-associated in utero undernutrition was related to changes in insulin action on gene expression of molecules involved in the insulin signaling pathway and peripheral glucose metabolism in muscle and adipose tissue. Thirteen insulin-resistant subjects born with intrauterine growth retardation (IUGR) were matched for age, gender, ...
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Introduction: Diabetes mellitus (DM) is now seen as a worldwide epidemic disease with high prevalence. Exercise training (ET) is known to promote beneficial changes in diabetic patients. The aim of this study was to compare the impact of continuous and intermittent aerobic training on glucose-4 transporter protein (GLUT-4) levels and insulin sensitivity in diabetic rats. Materials and meth...
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Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance. The insulin signal mechanism to intra-cells occurs in insulin resistance, primarily in adipose tissue cells, which can be appropriate targets for therapeutic approaches by recognizing the proteins in this pathway. The st...
متن کاملInsulin resistance and glucose transporter expression during the euglycemic hyperinsulinemic clamp in the lamb.
Three- to six-day-old lambs infused with 100 mU ⋅ kg-1 ⋅ min-1insulin required greater amounts of glucose to maintain euglycemia during a euglycemic hyperinsulinemic clamp compared with 31- to 35-day-old insulin-infused lambs (15.87 ± 3.47 vs. 4.30 ± 1.11 mg ⋅ kg-1 ⋅ min-1, P < 0.05, respectively). Endogenous glucose production persisted in both groups; however, the percent decrease compared wi...
متن کاملTargeting of the insulin-regulatable glucose transporter (GLUT-4).
668 A family of facilitative glucose transporters (GLUTS 1-7) has recently been identified in mammals [ 11. It is of key interest to determine the unique function of each GLUT isoform in an effort to broaden our understanding of whole body glucose homeostasis. An isoform of relevance to the regulation of glucose metabolism by insulin is GLUT-4. The expression of this isoform is confined to tiss...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2009
ISSN: 0085-2538
DOI: 10.1038/ki.2008.691